4-Substituted quinolines as antitumor agents

摘要

The invention concerns compounds of formula (I), wherein each of R¹, R², R³, R⁴, R⁵, R⁶, R⁸, R⁹, R¹⁰ m, n, p, X, Y and Z have any meanings defined in the description, processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-proliferative agent in the treatment of solid tumour disease.