COMBINATION OF CERAMIDE AND OXALIPLATIN FOR INDUCING CELL DEATH AND USES THEREOF IN TREATING CANCER

摘要

A method for increasing apoptosis in a cancer cell and a method of decreasing the size of a tumor comprising contacting the cancer cell with (a) oxaliplatin and (b) C6-ceramide, sequentially or concomitantly, wherein the oxaliplatin and C6-ceramide are in amounts such that the apoptosis or decrease in tumor size induced by the combination of oxaliplatin and C6-ceramide is greater than the apoptosis or decrease in tumor size induced by contacting the cancer cell with either oxaliplatin alone or C6-ceramide alone. A pharmaceutical composition and a method for treating a subject afflicted with cancer are disclosed.