ANTIGENIC PROTEOLIPOSOMES AND METHOD OF MANUFACTURE
摘要
<p>The present invention relates to a lipid vesicle comprising a lipid bilayer membrane and inserted into said membrane at least one antigenic peptide or protein, wherein said at least one peptide or protein is anchored in the membrane without involvement of a crosslinker in a site-oriented manner such that at least an antigenic part of said peptide or protein extends from the vesicle surface membrane to the exterior and is presented essentially in a physiologically functional, particularly in its native conformation, and wherein upon administration to a mammalian immune system said vesicle causes a strong immune response. The invention further relates to a method of manufacture of said lipid vesicles and to methods of their use as medicaments and in the manufacture of vaccines for prophylactic or therapeutic treatment of viral or non-viral infections.</p>
