发明名称 |
METHODS FOR PROMOTING MYELINATION, NEURONAL SURVIVAL AND OLIGODENDROCYTE DIFFERENTIATION VIA ADMINISTRATION OF SP35 OR TRKA ANTAGONISTS |
摘要 |
This invention relates to methods for promoting myelination, neuronal survival, and oligodendrocyte differentiation and treating demyelination and dysmyelination disease by the administration of a TrkA antagonist. The invention also relates to methods of inhibiting or decreasing Sp35 expression by the use of a TrkA antagonist. Additionally, the invention relates generally to methods for blocking Sp35 and TrkA interaction and inhibiting or decreasing TrkA phosphorylation by the administration of a Sp35 antagonist. |
申请公布号 |
WO2008013782(A2) |
申请公布日期 |
2008.01.31 |
申请号 |
WO2007US16589 |
申请日期 |
2007.07.24 |
申请人 |
BIOGEN IDEC MA INC.;MI, SHA;JUNG, VINCENT |
发明人 |
MI, SHA;JUNG, VINCENT |
分类号 |
A61K48/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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