Method for Producing Optically Active Cyclopropanecarboxylate Compound

摘要

A method for producing an optically active cyclopropanecarboxylate compound represented by the formula (5): wherein R⁶, R⁷, R⁸ and R⁹ represent a C1-C6 alkyl group or the like and R¹⁰ represents a C1-C6 alkyl group, which comprises reacting an olefin represented by the formula (3): wherein R⁶, R⁷, R⁸ and R⁹ are as described above, with a diazoacetic acid ester represented by the formula (4): N₂CHCO₂R¹⁰ (4) wherein R¹⁰ is as described above, in the presence of an asymmetric copper complex obtained by mixing (A) at least one monovalent or divalent copper compound, (B) at least one optically active bisoxazoline compound represented by the formula (1): wherein R¹ and R² represent a C1-C6 alkyl group or the like; R³ represents a tert-butyl group or the like; and R⁴ and R⁵ are the same and represent C1-C3 alkyl groups or the like, and (C) at least one fluorine compound represented by the formula (2): A-MF₆ (2) wherein A represents a trityl group or the like, and M represents a phosphorous atom or the like.