Method for the treatment of fibrosis using an antagonist of the integrin alpha-4 subunit

摘要

Disclosed is the use of a anti-alpha4 antibody or fragment thereof for the preparation of a pharmaceutical composition for the treatment of pulmonary fibrosis in a subject in need of treatment thereof. The anti-alpha4 antibody is an antagonist of an interaction between an alpha4 subunit-bearing integrin and a ligand for an alpha 4 subunit bearing integrin. With a proviso that the antigen binding region is not derived from a variable domain of the antibody produced by the cell line ATCC CRL 11175 and two other peptide sequences.