PURIFICATION METHOD OF CRUDE NAPHTHALENE DICARBOXYLIC ACID USING BENZALDEHYDE DEHYDROGENASE FROM RECOMBINATED MICROORGANISM AND 2,6-NAPHTHALENE DICARBOXYLIC ACID IN CRYSTALLINE FORM OBTAINED BY USING THE SAME

摘要

Disclosed is a method for purifying a crude naphthalene dicarboxylic acid using benzaldehyde dehydrogenase. According to the purification method, a crude naphthalene dicarboxylic acid is purified by reacting benzaldehyde dehydrogenase having the ability to convert 2-formyl-6-naphthoic acid to 2,6-naphthalene dicarboxylic acid with a crude naphthalene di¬carboxylic acid, thereby removing the 2-formyl-6-naphthoic acid from the crude naphthalene dicarboxylic acid, adding an acidic solution to the reaction solution under particular conditions, allowing the mixed solution to react with stirring to crystallize the crude naphthalene dicarboxylic acid, washing the crystal of the crude naphthalene dicarboxylic acid, and drying the washed product to obtain 2,6-naphthalene dicarboxylic acid in a pure crystalline form. Advantageously, the purification method enables the production of high-purity crystalline 2,6-naphthalene dicarboxylic acid on an industrial scale in an environmentally friendly manner.