| 摘要 |
Provided herein are novel APOBEC3G polypeptides having an amino acid substitution at position 129, e.g., P129D in which the polypeptide is capable of resisting proteosomal degradation induced by HIV-Vif. Also provided are isolated nucleic acids encoding the APOBEC3G polypeptides, recombinant vectors comprising the nucleic acids, recombinant host cells comprising the nucleic acid molecules encoding the polypeptides, pharmaceutical composition comprising the encoded protein, methods for resisting proteosomal degradation induced by HIV-Vif and thereby reducing or inhibiting HIV-1 and/or HIV-2 infection.
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