Formulations of an active pharmaceutical agent suitable for oral spray administration for absorption through the oral mucosa and related methods of preparation and administration are provided. Preferred embodiments provide sumatriptan succinate in a potassium phosphate buffer, wherein when a unit dose volume of about 50 to about 600 mcL of the oral spray composition is sprayed, a blood concentration of greater than about 5 ng/ml of sumatriptan is reached within about six minutes post dosing.
