METHOD FOR SEPARATING OPTICALLY ACTIVE N-SUBSTITUTED PROLINE

摘要

PROBLEM TO BE SOLVED: To provide a method for efficiently and industrially resolving an optical isomer mixture of N-substituted proline. SOLUTION: The method for separating an optically active N-substituted proline comprises bringing a preparative optical-isomer separating agent comprising a compound selected from the group consisting of an optically active polymaleimide derivative represented by general formula (1) and other optically active polymaleimide derivatives having other specific structures into contact with an optical isomer mixture of N-substituted proline having a specific structure. The preparative optical-isomer separating agent of N-substituted proline has high separation ability. The preparative packed column is packed with the optical-isomer separating agent. The method for separating an optically active N-substituted proline is provided. COPYRIGHT: (C)2008,JPO&INPIT