| 发明名称 |
USE OF INHIBITORS OF PP2C FOR TREATING OR PREVENTING ARTERIOSCLEROSIS |
| 摘要 |
Activity of serine-/threonine protein Phosphatase type 2C (PP2C) is known to be stimulated by certain unsaturated fatty acids and this enzyme dephosphorylates BAD1 thus acting on apoptosis. The invention provides saturated fatty acid (SFA) as new inhibitors for the activity of the PP2C. Therefore, the invention offers a new therapeutic strategy for the treatment and prevention of arteriosclerosis. |
| 申请公布号 |
WO2007137864(A9) |
申请公布日期 |
2008.01.31 |
| 申请号 |
WO2007EP04870 |
申请日期 |
2007.06.01 |
| 申请人 |
EUCRO EUROPEAN CONTRACT RESEARCH GMBH & CO. KG;GREB, WOLFGANG;KLUMPP, SUSANNE;KRIEGLSTEIN, JOSEF |
发明人 |
GREB, WOLFGANG;KLUMPP, SUSANNE;KRIEGLSTEIN, JOSEF |
| 分类号 |
A61K31/20;A61K31/00;A61K31/201;A61K31/202;A61K31/23;A61K31/231;A61K31/232;A61K31/685;A61P9/10;C12Q1/42 |
主分类号 |
A61K31/20 |
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