FLUORESCENT SUBSTRATES FOR MONOAMINE TRANSPORTERS AS OPTICAL FALSE NEUROTRANSMITTERS

摘要

The present invention relates to compounds of the general structure: wherein Y is O, X is O, bond a is absent and bond ß is present, or Y is H, X is CH, bond a is present, and bond ß is absent; atom Z is a carbon and bonds ?, d and ? are present, or is a nitrogen and bonds ?, d and ? are absent; R₁ is -H, -OH, -O-R₇, -N(H) -R₈, -N (H) - (CH₂) _n-NH₂, -N(R₉) (R₁₀), or a piperazine cation; R₂ is either covalently bound to R₉, or is -H, or is covalently bound to R₃ so as to form a substituted or unsubstituted pyrrole or R₂ is covalently bound to R₉ or R₈ or R₇; or R₁ and R₂ are covalently joined to form an aromatic ring; R₃ is either covalently bound to R₂ so as to form a pyrrole, or is, inter alia, -H, -OH, alkyl, or when Z is nitrogen R₃ is =O; R₄ is, inter alia, -H, -OH, or -R₁₁NH₂; R₅ is, inter alia, -H, -OH, or -R₁₂NH₂, and R₆ is either is covalently bound to R₁₀ or is -H, or R₆ is covalently bound to R₁₀ or R₈ or R₇. This invention also provides processes for making the compounds as well as methods for monitoring activity of monoamine transporters or treating monoamine transporter-associated diseases by employing the compounds.