SVV-BASED ANIMAL VACCINES AND USES THEREOF

摘要

Seneca Valley Virus (SVV) is a unique picornavirus that can specifically kill certain types of human tumor cells, but cannot infect, replicate within or kill normal human cells. It has been determined that SVV is also permissive to porcine cells, and shares high genomic sequence identity to a number of porcine picornaviruses, herein considered to be members of a group called SVV-like picornaviruses. Antibodies that can neutralize SVV infection of SVV permissive cell lines have been found to be cross-reactive to the SVV-like picornaviruses. Because these SVV-like picornaviruses may be associated with a variety of diseases and sicknesses in pigs, vaccines comprising SVV or S W-like picornaviruses may be useful for the protection of non-primate animals against picornavirus related infection and disease, including disease and sickness that may be associated with SVV and SVV-like picornavirus infection.