NOVEL PEPTIDE

摘要

This invention relates to a peptide of the formula I: B-Cys-X-Lys-Lys-Z-Gly-B¹X¹ (I) wherein: B is a sequence of 1-10 amino acid residues or an amino terminal group; X is a sequence of 1-4 amino acid residues which may be the same or different, the or each amino acid residue having a pK >7; Z is a sequence of 2-4 amino acid residues with the proviso that the first amino acid residue in the sequence and which is linked to the preceding lysine residue has a pK>7; B1 is a sequence of two amino acids, which may be the same or different, selected from lysine and/or arginine; and XI is a sequence of 1-15 amino acid residues or a carboxy- terminal group comprising at least one amino acid residue having a polar, uncharged side chain or a positively charged side chain at pH 7.0 (pK>7); or a pharmaceutically acceptable salt thereof. The formula I peptide has anti-microbial activity, especially anti-bacterial and anti-fungal activity.