| 摘要 |
A glycopeptide of the formula S-L-X-P, wherein: S is selected from an optionally protected monosaccharide, an optionally protected polysaccharide, a polyalkylene oxide chain and a group of the formula II, wherein R1 and R3 are independently selected from H or Ac, R4 is Ac, and R2 is a group of formula IV, wherein R7 and R8 are each independently selected from an optionally protected monosaccharide and an optionally protected polysaccharide, A, B, C and D are each independently 1 or 2, and m is 1 to 5; -L- is a moiety of the formula III, wherein R5 and R6 are independently selected from H and Me and n is 1 to 3; and P is a peptide chain containing at least one amino acid having on its side chain the atom X, wherein X is an oxygen or a sulphur atom. Compounds of formula S-L-Hal, their use in the preparation of compounds of formula S-L-X-P and the use of compounds of formula S-N3 to in turn synthesise compounds of formula S-L-Hal, where S and L are as defined above and Hal is Br or I, are also claimed. |
