摘要 |
Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha<SUB>2B </SUB>and/or alpha<SUB>2C </SUB>adrenergic receptors in preference over alpha<SUB>2A </SUB>adrenergic receptors, and as such have no or only minimal cardivascular and/or sedatory activity. These compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha<SUB>2B </SUB>adrenergic receptors. Compounds of Formula 1 where X is O also have the advantageous property that they have no or only minimal cardivascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardivascular and/or sedatory activity.
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