发明名称 |
NOVEL ANANDAMIDE AMIDASE INHIBITORS AS ANALGESIC AGENTS |
摘要 |
Disclosed is a method of inhibiting anandamide amidase in an individual or animal and novel inhibitors of anandamide amidase. Compounds of the invention are represented by Structural Formula (I): R-X-Y (I) wherein R is selected from the group consisting of a methyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, and an optionally substituted heterocyclic group; X is an optionally substituted straight chain hydrocarbyl group containing from 10-24 carbon atoms if R is a methyl group, and from 4-18 carbon atoms if R is an optionally substituted aryl group, an optionally substituted heteroaryl group, or an optionally substituted heterocyclic group; and Y is a moiety capable of irreversibly binding to a nucleophilic group at the active site of an amidase enzyme.
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申请公布号 |
CA2255620(C) |
申请公布日期 |
2008.01.29 |
申请号 |
CA19972255620 |
申请日期 |
1997.05.30 |
申请人 |
UNIVERSITY OF CONNECTICUT |
发明人 |
LIN, SONYAN;HILL, WILLIAM ADAM;MAKRIYANNIS, ALEXANDROS |
分类号 |
C07D207/46;C07D239/22;A61K31/00;A61K31/185;A61K31/22;A61K31/221;A61K31/255;A61K31/33;A61K31/40;A61K31/4015;A61P1/00;A61P1/08;A61P27/00;A61P27/06;A61P29/00;A61P37/00;A61P37/06;A61P43/00;C07C259/06;C07D401/06;C07D403/06;C07D405/06;C07D409/06;C07D413/06;C07D417/06 |
主分类号 |
C07D207/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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