Pyridine and pyrimidine derivatives

摘要

Compounds of formula (1) are described in which R^a and R^b is each independently a hydrogen atom or a group R^c, or R^a and R^b together form an oxo (-O) or thio (-S) group; X is a N atom or an optionally substituted CH group: Y is a -O- or -S- atom or -SO- or -SO₂- group or an optionally substituted -CH₂- or -NH- group with the proviso that when R^a and R^b together form an oxo (-O) or thio (-S) group Y is an optionally substituted -CH₂- or -NH-group; L¹ is a covalent bond or a linker atom or group; p is zero or the integer 1; Alk¹ is an optionally substituted C_1-10aliphatic or C_1-10heteroaliphatic chain; n is zero the integer 1, 2 or 3 with the proviso that when n is zero Y is an optionally substituted -CH₂- group; Ar is an optionally substituted C_6-12aromatic or C_1-9heteroaromatic group; m is zero or the integer 1, 2 or 3; q is zero or the integer 1 or 2; R¹, R^c and R^d are hydrogen atoms or the substituents described in the patent specification; and the salts, solvates, hydrates and N-oxides thereof. The compounds are potent and selective inhibitors of p38 kinase and are useful in the treatment of immune or inflammatory disorders.