| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to compounds of formula which exhibits an inhibiting action on protein kinases A and B. In the compounds of formula (I), A represents a saturated hydrocarbon binding group containing 1 to 7 carbon atom where the binding group includes a chain of the maximum length 5 atoms located between R1 and NR2R3, and a chain of the maximum length 4 atoms located between E and NR2R3 where one of carbon atoms in the binding group can be optionally substituted by an oxygen or nitrogen atom; and where the carbon atoms of the binding group A can optionally have one or more substitutes selected from oxo, fluorine and hydroxy provided the hydroxy group if any is not located on a carbon -atom in relation to the NR2R3 group and provided the oxo group if any is located on the carbon -atom in relation to the NR2R3; E represents a phenyl or pyridine group; R1 represents a C6-10aryl or pyridyl group which is not substituted or substituted with 1 or 2 substitutes specified in the patent claim; and R2, R3, R4 and R5 have the values specified in the points of the patent claim. ^ EFFECT: invention refers to a pharmaceutical composition containing said compounds, to methods of making the compounds and their application as cancer drugs. ^ 29 cl, 1 tbl, 108 ex |
