| 摘要 |
The invention relates to medicine and pharmacology, in particular to liposomal compositions of antioxidants suitable for inhalations in lung and upper respiratory tract diseases. The present composition of antioxidants for inhalation in lung and upper respiratory tract diseases represents an emulsion of phospholipids in form of liposomes with an average particle size of 0.2-0.4 μm, in the membrane of which the flavonoid dihydroquercetin and wheat germ oil are introduced. The latter contains the hydrophobic antioxidants tocopherols (TP) (vitamin E) and carotenoids. The aqueous phase of the emulsion contains sodium chloride, the water-soluble antioxidants ascorbic acid (vitamin C), N-acetyl-L-cysteine and sodium benzoate. The composition of antioxidants is selected in order to provide the possibility of administering the individual vitamins in minimum doses, and to ensure that the content of active, not oxidized form of the antioxidants is not reduced during storage. |
