METHODS AND COMPOSITIONS FOR MODULATING SOCS3

摘要

The expression of suppressor of cytokine signalling 3 (SOCS3) in mammalian cells is controlled via modulating the expression and/or activity of Foxp3 in the cell. Modulation of Foxp3 homodimer formation or activity allows for control of SOCS3 expression. SOCS3 is an inhibitor of several intracellular signal transduction pathways, including the LIF signalling pathway. Modulators of Foxp3 homodimer activity and/or expression that are able to control the expression of SOCS3 in a cell are useful as immunomodulators.