METHODS, COMPOSITIONS, AND KITS FOR THE SELECTIVE ACTIVATION OF PROTOXINS THROUGH COMBINATORIAL TARGETING

摘要

The present invention provides methods and compositions for treating various diseases through selective killipg of targeted cells µsing a combinatorial targeting approach. The invention features protoxin fusion proteins containing a cell targeting r?oiety and, a modifiable activation moiety which is activated by an activation moiety not riaturally operably found in, on, or in the vicinity of a target cell. These methods also include the combinatorial use of two or more therapeutic agents, at minimum comprising a protoxin and a protoxin activator, to target and destroy a specific cell population.