摘要 |
Novel 2-substituted methyl penam derivatives include the formula (I), their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their solvates, their pharmaceutically acceptable salts, and pharmaceutical compositions containing them; wherein A = C or N; Het is a three- to seven-membered heterocyclic ring; R<SUP>1</SUP> represents carboxylate anion, or -COOR<SUP>4</SUP> where R<SUP>4</SUP> represents hydrogen, carboxylic acid protecting group or a pharmaceutically acceptable salt; R<SUP>2</SUP> and R<SUP>3</SUP> may be same or different and independently represent hydrogen, halogen, amino, alkyl, protected amino, optionally substituted alkyl, alkenyl, alkynyl and the like; R represents substituted or unsubstituted alkyl, alkenyl, aryl, aralkyl, cycloalkyl, heterocyclyl or heterocyclylalkyl. |
申请人 |
ORCHID CHEMICALS & PHARMACEUTICALS LIMITED;UDAYAMPALAYAM, PALANISAMY, SENTHILKUMAR;GNANAPRAKASAM, ANDREW;GANAPATHY, PANCHAPAKESAN;MUKUT, GOHAIN;VENKATASUBRAMANIAN, HARIHARAN;SRIRAM, RAJAGOPAL;PAUL-SATYASEELA, MANEESH;SOLANKI, SHAKTI, SINGH;DEVARAJAN, SATHISHKUMAR |
发明人 |
UDAYAMPALAYAM, PALANISAMY, SENTHILKUMAR;GNANAPRAKASAM, ANDREW;GANAPATHY, PANCHAPAKESAN;MUKUT, GOHAIN;VENKATASUBRAMANIAN, HARIHARAN;SRIRAM, RAJAGOPAL;PAUL-SATYASEELA, MANEESH;SOLANKI, SHAKTI, SINGH;DEVARAJAN, SATHISHKUMAR |