HIGH-MOLECULAR WEIGHT CONJUGATE OF COMBRETASTATINS

摘要

A novel derivative of a combretastatin which has water solubility and is capable of releasing a drug independent of biological enzymes in which indiv idual differences are likely caused and whose effective therapeutic effect c an be expected has been demanded.A polymer conjugate of a combretastatin, ch aracterized by having a structure in which a hydroxy group of a combretastat in is linked via an ester bond to a carboxylic acid group of the following p olymer moiety in a block copolymer of a polyethylene glycol structure moiety with a polymer moiety having two of more carboxylic acid groups such as pol yaspartic acid or polyglutamic acid is provided.