VACCINES FOR MALARIA

摘要

The present invention relates to a lipoprotein particle, methods for prep aring and purifying the same, its use in medicine, particularly in the preve ntion of malarial infections, compositions/vaccines containing the particle or antibodies against the protein particle such as monoclonal or polyclonal antibodies and use of the same, particularly in therapy. In particular it re lates to an immunogenic protein particle comprising the following monomers: a. a fusion protein comprising sequences derived from a CS protein of P. viv ax and the S antigen of Hepatitis B (CSV-S), and b. a fusion protein compris ing sequences derived from CS protein of P. falciparum and S antigen of Hepa titis B (RTS), and c. optionally the S antigen derived from Hepatitis B.