发明名称 QUINAZOLINE AND PYRIDOPYRIMIDINE DERIVATIVES AS P38 KINASE INHIBITORS
摘要 The present invention comprises a new class of compounds useful for the p rophylaxis and treatment of protein kinase mediated diseases, including infl ammation and related conditions. The compounds have a general Formula I wher ein A1, A2, B, s, T, R1, R2, R3 and R4 are defined herein. The invention als o comprises pharmaceutical compositions including one or more compounds of F ormula I, methods of use such as treatment of kinase mediated diseases by ad ministering the compounds of Formula I or compositions including the compoun ds of Formula I, and intermediates and processes useful for the preparation of compounds of Formula I.
申请公布号 CA2656507(A1) 申请公布日期 2008.01.24
申请号 CA20072656507 申请日期 2007.07.16
申请人 AMGEN, INC. 发明人 TADESSE, SEIFU;TASKER, ANDREW;HONG, FANG-TSAO;SHAM, KELVIN, K. C.
分类号 C07D239/82;A61K31/495;A61P3/00;A61P29/00;A61P35/00;C07D471/04 主分类号 C07D239/82
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