发明名称 |
Cancer Treatment and Cancer Treatment Efficacy Prediction by Blocking and Detecting Protease Inhibitors |
摘要 |
Disclosed is a method for improving cancer therapy that relies on induction of apoptosis in malignant cells. It has been found that docking of protease inhibitors PAI-1 and TIMP-1 renders malignant cells expressing these inhibitors more sensitive to apoptosis, whereas non-malignant cells do not change their sensitivity to apoptosis induction. It is therefore possible to increase the effect of various anti-cancer treatments in a rational manner and to predict whether or not an apoptosis-inducing cancer treatment will be effective in a patient or not. The invention also provides for methods of identifying agents that inhibit the apoptosis sensitivity modulating effects of protease inhibitors and to methods of identifying anti-cancer compounds that are not dependent on an apoptosis inducing mechanism which can be modulated by protease inhibitors.
|
申请公布号 |
US2008019910(A1) |
申请公布日期 |
2008.01.24 |
申请号 |
US20050594999 |
申请日期 |
2005.03.30 |
申请人 |
ROMER MARIA U;LADEMANN ULRIK A;HOFLAND KENNETH F;JENSEN PETER B;VAN GELDER MARION E M;FOEKENS JOHANNES A;RASMUSSEN ANNE-SOFIE S;BRUNNER NILS A;USHER PERNILLE A |
发明人 |
ROMER MARIA U.;LADEMANN ULRIK A.;HOFLAND KENNETH F.;JENSEN PETER B.;VAN GELDER MARION E.M.;FOEKENS JOHANNES A.;RASMUSSEN ANNE-SOFIE S.;BRUNNER NILS A.;USHER PERNILLE A. |
分类号 |
A61K49/00;A61K31/337;A61K31/7052;A61K33/34;A61K38/02;A61K39/395;C12Q1/02;C12Q1/68;G01N33/574 |
主分类号 |
A61K49/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|