PROCESS FOR PRODUCING SPHERICAL ELEMENTARY GRANULE CONTAINING READILY WATER-SOLUBLE DRUG

摘要

A process for producing spherical elementary granules containing a readily water-soluble drug which comprises spraying a layering liquid over pharmacologically inert, spherical core particles to coat them with a layer containing a readily water-soluble drug.In the process, (1) the spherical core particles have a crystalline-celluose content of 30 mass% or higher and a water retentivity of 0.5 cm³/g or higher and (2) the layering liquid is an aqueous solution at least containing a readily water-soluble drug and a poorly water-soluble saccharide. The elementary granules are suitable for film coating.