发明名称 |
C-Purine Nucleoside Analogs As Inhibitors Of Rna-Dependent Rna Viral Polymerase |
摘要 |
The present invention provides C-purine nucleoside analogs and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such C-nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the C-nucleoside compounds of the present invention.
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申请公布号 |
US2008021047(A1) |
申请公布日期 |
2008.01.24 |
申请号 |
US20050628513 |
申请日期 |
2005.06.10 |
申请人 |
BUTORA GABOR;MACCOSS MALCOLM;BHAT BALKRISHEN;ELDRUP ANNE B |
发明人 |
BUTORA GABOR;MACCOSS MALCOLM;BHAT BALKRISHEN;ELDRUP ANNE B. |
分类号 |
A61K31/52;A61K31/513;A61K31/519;A61K31/522;A61P31/12;C07D473/18;C07D473/34;C07D487/04;C07D491/04;C07D491/048;C07D498/04 |
主分类号 |
A61K31/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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