| 摘要 |
<p>The present invention relates to compounds of general formula (I):
wherein:
- R 1 , R 2 and R 3 mean, independently from the others, an hydrogen atom or an optionally substituted lower alkyl, a (C 1 -C 7 )acyl group or a benzyl,
- R 4 is an optionally substituted and/or interrupted hydrocarbon linker,
- X and Y are selected independently from each other from the group consisting of -NH-, -NR'-, -CO-, -NH(CO)-, -NH(CO)NH-, -NR'(CO)-, -O(CO)NH-, -O(CO)NR'-, -(CO)NH-, -(CO)NR'-, -NH(CO)(R")NH(CO)-, -(CO)NH(R"(CO)NH-, -O-, -(CO)O-, -NH(CO)O-, -SC(O)NH-, -NHSO 2 -, -NR'SO 2 - and -O(CO)- and preferably are different one from the other, with R' being an optionally substituted lower alkyl group, and R" being a (C 1 -C 3 ) alkylene,
- Z moiety represents an anti-neoplasic agent,
- n means 0 or 1,
- and the pharmaceutically acceptable salts thereof.
It relates also to the use of such compounds as anti cancer agents.</p> |
