摘要 |
<p>The present invention provides nitrogen-containing heterocyclic derivatives represented by the general formula: wherein X<SUP>1 </SUP>and X<SUP>3 </SUP>independently represent N or CH; X<SUP>2 </SUP>represents N or CR<SUP>2</SUP>; X<SUP>4 </SUP>represents N or CR<SUP>3</SUP>; and with the proviso that one or two of X<SUP>1</SUP>, X<SUP>2</SUP>, X<SUP>3 </SUP>and X<SUP>4 </SUP>represent N; R<SUP>1 </SUP>represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a lower alkoxy-substituted (lower alkyl) group, a lower alkoxy-substituted (lower alkoxy) group, a lower alkoxy(lower alkoxy)-substituted (lower alkyl) group, a cyclic lower alkyl group, a halo(lower alkyl) group or a group represented by the general formula: HO-A- wherein A represents a lower alkylene group, a lower alkyleneoxy group or a lower alkylenethio group; R<SUP>2 </SUP>represents a hydrogen atom, a halogen atom, a lower alkyl group, a cyclic lower alkyl group, a lower alkoxy group, an amino group, a (lower acyl)amino group, a mono(lower alkyl)amino group or a di(lower alkyl)amino group; and R<SUP>3 </SUP>represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, or prodrugs thereof which are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutical compositions comprising the same, and pharmaceutical uses and production intermediates thereof.</p> |
申请人 |
KISSEI PHARMACEUTICAL CO., LTD. |
发明人 |
NISHIMURA, TOSHIHIRO;FUJIKURA, HIDEKI;FUSHIMI, NOBUHIKO;TATANI, KAZUYA;KATSUNO, KENJI;ISAJI, MASAYUKI |