发明名称 |
MICROBIOLOGICAL PROCESS FOR THE PREPARATION OF HETEROAROMATIC CARBOXYLIC ACIDS USING MICROORGANISMS OF THE GENUS ALCALIGENES |
摘要 |
A microbiological process for the preparation of heteroaromatic carboxylic acids or physiologically tolerated salts thereof, of the general formulae: <IMG> in which R1 and R2 are identical or different and denote a hydrogen or halogen atom and X denotes a nitrogen atom or -CH-, is described herein. The conversion is carried out in such a way that heteroaromatic nitriles of the general formulae: <IMG> in which R1, R2 and X are as previously defined, are converted as substrate, using 2-cyanopyridine-utilizing microorganisms of the genus Alcaligenes which have been cultured before the biotransformation in the presence of a dicarboxylic acid, tricarboxylic acid or a carbohydrate, into the corresponding carboxylic acid, and the latter is converted where appropriate into a physiologically tolerated salt thereof.
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申请公布号 |
CA2177651(C) |
申请公布日期 |
2008.01.22 |
申请号 |
CA19962177651 |
申请日期 |
1996.05.29 |
申请人 |
RODUIT, JEAN-PAUL;GLOCKLER, RAINER;KIENER, ANDREAS |
发明人 |
RODUIT, JEAN-PAUL;GLOCKLER, RAINER;KIENER, ANDREAS |
分类号 |
C12P17/10;C12P17/12;C07D213/79;C07D241/24;C12P17/14;C12R1/05 |
主分类号 |
C12P17/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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