发明名称 |
HUMAN DNASE I HYPERACTIVE VARIANTS |
摘要 |
The present invention relates to amino acid sequence variants of human DNase I that have increased DNA-hydrolytic activity. The invention provides nucleic acid sequences encoding such hyperactive variants , thereby enabling the production of these variants in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic uses of hyperactive variants of human DNase I.
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申请公布号 |
CA2257133(C) |
申请公布日期 |
2008.01.22 |
申请号 |
CA19972257133 |
申请日期 |
1997.06.09 |
申请人 |
GENENTECH, INC. |
发明人 |
PAN, CLARK QUN;LAZARUS, ROBERT A. |
分类号 |
C12N15/09;C12N15/55;A61K9/08;A61K38/00;A61K38/46;A61P11/00;A61P11/12;A61P37/00;C12N9/16;C12N9/22;C12R1/91 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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