| 摘要 |
FIELD: medicine; chemical and pharmaceutical industry. ^ SUBSTANCE: invention in the field of pharmaceutical forms, namely relates to systems delivering water-insoluble and poorly soluble bioactive substances by solubilizing them in water-soluble amphiphilic polymers, containing at least one segment of water-soluble carbon-chain polymer with molecular weight Mn = 1000-20000, and at least one end hydrophobic alkyl with 6-25 atoms of hydrogen in the hydrogen chain, by self-association of diphilic substances in water media at critical concentration of micelles or at critical concentration of aggregation with formation of spherical particles 5-1500 nm large. Besides, the invention is associated with delivery of water-insoluble or poorly soluble pharmaceutical forms generated by this method. ^ EFFECT: better compatibility of water-insoluble and poorly soluble bioactive substances with water. ^ 43 cl, 2 tbl, 5 ex |
