| 摘要 |
<p>The present invention relates to an improved process for the preparation of 6-O-methylerythromycin A derivatives, intermediates of clarithromycin, by selective methylation of erythromycin A derivative in a mixture of a acyclic or cyclic alkanes having C<SUB>6</SUB>-C<SUB>10</SUB> carbon atoms, and a polar aprotic solvent using a methylating agent in the presence of a base under mild conditions.</p> |
