| 摘要 |
FIELD: medicine. ^ SUBSTANCE: claimed is biopolymer with expressed immunostimulating effect, consisting of highly molecular fragment of peptidoglican of cell wall of Gram-negative bacteria, whose repeating link (RL) represents tetrasaccharide 4-O-{4-O-[4-O-(N-acetyl--D-glucosaminyl)-N-acetyl--D-muramyl]-N-acetyl--D-glucosaminyl}-N-acetyl-D-muramic acid, to which on carboxyl groups of both residues of muramic acid bound is tetrapeptide residue: N-(L-alanyl-D-isoglutaminyl-meso-diaminopimelonyl-D-alanine). Binding between RL is perfomed due to octapeptide bridges (dwg.1), number of RL constituting from 5 to 20 or their combination. Also claimed are method of biopolymer obtaining, based on it pharmaceutical immunostimulating composition and its application in methods of stimulating immune system of mammals and non-specific protection against bacterial infections. ^ EFFECT: possibility of application in immunopharmacology, in particular, for creation of medications of supporting therapy, intended for enhancing immune resistance of organism. ^ 11 cl, 2 dwg, 2 tbl, 5 ex |
