| 发明名称 |
N-HETEROCYCLIC INHIBITORS OF TNF-ALPHA EXPRESSION |
| 摘要 |
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I): Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-alpha expression utilizing compounds of the present invention are also disclosed.
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| 申请公布号 |
US2008015185(A1) |
申请公布日期 |
2008.01.17 |
| 申请号 |
US20070778219 |
申请日期 |
2007.07.16 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
AHMED GULZAR;METZGER AXEL;HENDERSON IAN;DILLER DAVID J.;WEN JUN;WROBLESKI STEPHEN T.;LEFTHERIS KATERINA;LIU CHUNJIAN |
| 分类号 |
A61K31/513;A61K31/44;A61K31/505;A61K31/506;A61K31/55;A61K31/551;A61K31/56;A61P1/02;A61P1/04;A61P1/16;A61P1/18;A61P3/10;A61P7/02;A61P7/04;A61P7/06;A61P9/00;A61P9/04;A61P9/10;A61P11/00;A61P13/12;A61P17/00;A61P17/02;A61P17/06;A61P19/02;A61P19/06;A61P19/08;A61P19/10;A61P21/04;A61P25/00;A61P25/02;A61P25/16;A61P25/28;A61P27/02;A61P29/00;A61P29/02;A61P31/00;A61P31/12;A61P31/18;A61P35/00;A61P35/04;A61P37/02;A61P37/04;A61P37/06;A61P37/08;A61P43/00;C07D213/85;C07D239/48;C07D239/50;C07D401/12;C07D403/12;C07D403/14;C07D409/12 |
主分类号 |
A61K31/513 |
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