Methods and Compositions for Targeting Macromolecules Into the Nucleus

摘要

The present invention includes compositions, methods and kits for directing an agent across the nuclear membrane of a cell. The present invention includes a Karyopherin beta2 translocation motif in a polypeptide having a slightly positively charged region or a slightly hydrophobic region and one or more R/K/H-X_(2-5)-P-Y motifs. The polypeptide targets the agent into the cell nucleus.