| 摘要 |
The present invention provides stable pharmaceutical compositions compris ing a combination of active pharmaceutical ingredients. The pharmaceutical c omposition of the present invention comprises a moisture sensitive drug, in particular an angiotensin converting enzyme (ACE) inhibitor such as Cilazapr il, as an active ingredient, a second pharmaceutically active ingredient suc h as for example Hydrochlorothiazide, and at least one pharmaceutical excipi ent, wherein the moisture sensitive active pharmaceutical ingredient is wet granulated with a solution of at least one pharmaceutical excipient, and met hods for preparing such stable pharmaceutical compositions.
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