AGENTS FOR IMAGING APOPTOSIS

摘要

Compositions, and methods of using such compositions, having the following Formula (I) or salt, ester, or hydrate thereof, wherein R₁ is Asp-Glu peptide, tert-butyloxycarbonyl, methoxyphenylacetyl, bromomethoxyphenylacetyl, fluoromethoxyphenylacetyl, (methylmethoxyphenyl)acetyl, or iodomethoxyphenylacetyl; R₂ is valine (with or without protecting groups), aspartate (with or without protecting groups), t-Butyl, hydrogen, aniline, aromatic molecules, tert-butyloxycarbonyl, or fluorenyl-methoxy-carbonyl; and R₃ is p- nitroaniline, 7-amino-4-methylcoumarin, fluoroethylamine, l-amino-4-fluoromethyl- cyclohexane, l-amino-4-fluoroethyl-cyclohexane, aniline, p-fluoroaniline, p- fluoromethylaniline, p-fluorobenzylamine, p-fluoromethylbenzylamine, 4-aminopiperidine, 4-amino- 1 -fluoroethylpiperidine, or 4-amino- 1 -fluoropropylpiperidine.