Methods to elicit, enhance and sustain immune responses against MHC class I-restricted epitopes, for prophylactic and therapeutic purposes

摘要

Embodiments of the present invention relate to methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response. The methods and compositions disclosed herein, can be used for prophylactic or therapeutic purposes. Further embodiments provide methods of treating a cell proliferative disease, such as cancer by providing to a subject in need thereof a therapeutic strategy comprising an immunogenic composition in combination with a chemotherapeutic agent.