Dimeric Piperidine Derivatives

摘要

the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 0, 1 or 2; R² represents hydroxy; -X- represents C_2-4alkynyl, C_1-12alkyl optionally substituted with hydroxy or X represents a divalent radical of the formula wherein; -X₁- represents C_1-12alkyl, phenyl or a divalent radical selected from the group consisting of -X₂- represents C_1-12alkyl, C_1-4alkyloxyC_1-4alkyl, phenyl or a divalent radical of formula -X₃- represents phenyl or a divalent radical selected from the group consisting of R¹ independently represents hydrogen, C_1-4alkyl, C_1-4alkyloxy-, Ar¹, Ar²-carbonyl, Het¹-C_1-4alkyl, Het², NR³R⁴-C_1-4alkyl, Ar³-C_1-4alkyloxy- or Het⁴-oxy-; R³ and R⁴ each independently represents hydrogen, C_1-4alkyl, C_1-4alkyloxy-, or Het³; Het¹ represents a heterocycle selected from pyridinyl, indolinyl, indolyl, benzimidazolyl, benzthiazolyl, benzisoxazolyl, thiazolyl, pyridinyl, or thiadiazolyl wherein said Het¹ is optionally substituted with one or where possible two or more substituents selected from the group consisting of hydroxy, halo, C_1-4alkyloxycarbonyl-, C_1-4alkyl-, C_1-4alkyloxy- and C_1-4alkyloxy-substituted with halo; in particular Het¹ represents a heterocycle selected from indolyl or pyridinyl; Het² represents a heterocycle selected from indolyl, benzisoxazolyl or oxodiazolyl wherein said Het² is optionally substituted with one or where possible two or more substituents selected from the group consisting of hydroxy, halo, C_1-6alkyl- and C_1-4alkyloxy-; Het³ represents a heterocycle selected from benzimidazolyl, benzisoxazolyl or benzthiazolyl wherein said Het³ is optionally substituted with one or where possible two or more substituents selected from the group consisting of hydroxy, halo, C_1-6alkyl- and C_1-4alkyloxy-; in particular Het³ represents benzthiazolyl substituted with C_1-4alkyloxy-; Het⁴ represents a heterocycle selected from benzimidazolyl, benzisoxazolyl or benzthiazolyl wherein said Het⁴ is optionally substituted with one or where possible two or more substituents selected from the group consisting of hydroxy, halo, C_1-6alkyl- and C_1-4alkyloxy-; in particular Het⁴ represents benzthiazolyl; Ar¹ represents phenyl optionally substituted with halo, C_1-4alkyl or C_1-4alkyl substituted with one, two or three halo substituents; Ar² represents phenyl optionally substituted with halo, C_1-4alkyl or C_1-4alkyl substituted with one, two or three halo substituents; in particular Ar² represents phenyl substituted with halo or trifluromethyl; Ar³ represents phenyl optionally substituted with halo, C_1-4alkyl or C_1-4alkyloxy-.