MODIFIED CLOSTRIDIAL TOXINS WITH ENHANCED TRANSLOCATION CAPABILITIES AND ALTERED TARGETING ACTIVITY FOR CLOSTRIDIAL TOXIN TARGET CELLS

摘要

The specification discloses modified Clostridial toxins comprising a Clos tridial toxin enzymatic domain, a Clostridial toxin translocation domain, a translocation facilitating domain and an altered target domain; polynucleoti de molecules encoding such modified Clostridial toxins; and methods of produ cing such modified Clostridial toxins.