Fuel containers and hydrogen gas generation systems and methods are provided which comprise a fuel storage chamber and a hydrogen storage region separated by a partition including a gas permeable membrane to transport hydrogen to the hydrogen storage region. A hydrogen separation chamber and a volume-exchange configuration for the storage of a fuel solution and product material may be incorporated. Methods also are provided for regulating transfer of fuel solution to a reaction chamber and transfer of hydrogen and product to the hydrogen separation chamber, while maintaining a positive pressure differential from the fuel storage chamber to the hydrogen storage region.
