CHITOSAN COMPLEX CONTAINING PH SENSITIVE IMIDAZOLE GROUP AND PREPARATION METHOD THEREOF

摘要

Disclosed herein a chitosan complex containing a pH-sensitive imidazole group and a method for the preparation thereof. The amino group of glycol chitosan is linked via amide bond to the histidine of the imidazole, which is hydrophobic in a neural range, but hydrophilic in a weak acid region an imidazole group via an amide bond between the amino group of glycol chitosan. The chitosan complex can be loaded with various hydrophobic drugs, such as anticancer agents and gene, and labeled with traceable radioisotopes, so that it is useful as a drug delivery system, a scintigraphical tracer and a gene carrier.