BENZIMIDAZOLE COOLING COMPOUNDS

摘要

A method of providing a cooling sensation to the skin or mucous membranes of the mouth by applying thereto a quantity of at least one chemical compound sufficient to cause a desirable degree of cooling sensation, the chemical compound comprising a compound of formula (I) in which R¹, R² are independently in either the meta- or para-position and independently comprise at least one of hydrogen, halide, C₁-C₃ alkyl (linear or branched), halide, C₁-C₃ alkoxy, nitro, nitrile, amide or ester; R³ comprises at least one of C₁-C₅ alkyl or C₁-C₅ alkenyl groups (linear or branched), R⁴ comprises at least one of hydrogen, C₁-C₃ alkyl (linear or branched), or a halide. The cooling effect provided is in some instances superior to that achievable by any of the known commercial cooling agents.