| 摘要 |
Compounds of formula (I): Z is >CH-, >C=CH- or >N-, R1 and R2 ar e optionally substituted and are the same or different, and each represents an aryl group, a heteroaryl group, or Z, R1 and R2 form a fused ring structu re of formula: in which A represents a single bond, or linking group, R3 rep resents hydrogen, a group selected from: -AIkCOOR, -AIkNR7R8, -AIkCONR7R8, - AIkCOR9, -AIkSO2NR10R10', -AIkOR10, and -AIkS(O)nR10, in which AIk is alkyl, R is hydrogen or alkyl, R7 and R8 each represents H, optionally substituted alkyl, alkylaminoalkyl or dialkylaminoalkyl, or CONR7R8 forms an optionally substituted heterocycle, and R10 and R10 are hydrogen atom, optionally subs tituted alkyl, an alkylaminoalkyl group, an optionally substituted cycle, op tionally spaced by an AIk group as defined, Q represents >C=0 or >C=S, R5 is a hydrogen atom or an alkyl, alkoxy, hydroxyalkyl, alkylthio, or thio alkyl group, p is 1, 2 or 3, q is 0, 1 or 2, R6 represents an optionally sub stituted aryl or heteroaryl group, and salts and esters thereof, are useful as calcimimetics in therapy.
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