| 摘要 |
<p>A transdermal patch for administrating an agonist to a patient, where the transdermal patch includes an occlusive wall defining a reservoir with an open bottom end and an opposing top end, a matrix permeable to perspiration from the patient occupying the reservoir, wherein the matrix includes a first region having the agonist suspended therein for release through the bottom end of the reservoir to the patient, and a second region located at the top end of the reservoir, wherein the second region includes an antagonist associated with the agonist suspended therein and being configured to release the antagonist at the onset of imminent overdose of the agonist by the patient, a permeable adhesive layer covering at least a portion of the bottom end of the reservoir, the adhesive layer being adapted for maintaining the matrix in communication with the skin of the patient; and at least one visual indicator located at the top end of the reservoir, wherein the at least one visual indicator is adapted to undergo a visual change in the presence of the perspiration from the patient.</p> |
