摘要 |
Compound (II) is reacted with formate in the presence of an alkali metal alkoxide and the like to give compound (III); then this is reacted with compound (IVa) or compound (IVb) to give compound (V); then this is reacted with compound (VI) to give compound (VII); and then this is deprotected to give compound (I). The present invention provides an industrially advantageous production method of a 4-acetylpyrimidine compound useful as a synthetic intermediate for a pharmaceutical product: wherein X is a methylthio group and the like, R<SUP>1 </SUP>is a lower alkyl group and the like, R<SUP>2 </SUP>is a lower alkyl group optionally having substituent(s) and the like, M is an alkali metal and X<SUP>1 </SUP>is a halogen atom.
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