发明名称 |
SCFV ANTIBODIES WHICH PASS EPITHELIAL AND/OR ENDOTHELIAL LAYERS |
摘要 |
<p>scFv antibodies which specifically bind selected antigens and are obtainable by a method comprising (i) selecting from a pool of soluble and stable antibody frameworks a soluble and stable framework matching best the framework of a non-human antibody against the antigen with a certain binding specificity, (ii) either providing said soluble and stable framework with CDRs that bind specifically to said antigen, or mutating the framework of said non-human antibody towards the sequence of said soluble and stable framework, to generate scFv antibodies, (iii) testing the generated antibody for solubility and stability, and testing the generated antibody for antigen binding, and (iv) selecting an scFV that is soluble, stable and binds to the antigen specifically. Also provided are pharmaceutical compositions comprising said scFv antibody, methods of treatment and diagnosis for diseases related to over expression of antigens that are specifically bound by said antibody.</p> |
申请公布号 |
WO2008006235(A2) |
申请公布日期 |
2008.01.17 |
申请号 |
WO2007CH00334 |
申请日期 |
2007.07.10 |
申请人 |
ESBATECH AG;AUF DER MAUR, ADRIAN;BARBERIS, ALCIDE;URECH, DAVID;LICHTLEN, PETER |
发明人 |
AUF DER MAUR, ADRIAN;BARBERIS, ALCIDE;URECH, DAVID;LICHTLEN, PETER |
分类号 |
C07K16/24;A61K39/395;A61P27/02 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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